EFFECTS OF DRUGS ON PLATELET-FUNCTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 7  (1) , 68-72
Abstract
Numerous drugs and chemicals affect the function of human blood platelets. The mechanism of action of some medications is partly understood. Aspirin is the most frequently involved drug. It appears to interfere with the platelet release reaction by acetylation of a platelet membrane protein which may be involved in the synthesis of prostaglandins. Other anti-inflammatory drugs, including indomethacin, phenylbutazone, ibuprofen (Motrin) and clonixin, also interfere with the release reaction but have a shorter acting course than aspirin. Some drugs stimulate adenyl cyclase (gliclazide) or block phosphodiesterase, (dipyridamole, caffeine), both of which actions lead to an increase in cyclic AMP and decrease aggregation by ADP. These interactions should be known to clinical scientists since patients using these medicaments may manifest abnormal platelet function tests in the laboratory and mild hemorrhagic syndromes in the clinic.

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