Abstract
Estimating confidence intervals for the interaction between treatments and environmental conditions in binomial experiments is analyzed. Testing the interaction is studied also. The problem is reduced to that of estimating or testing the interaction parameter in 2 × 2 × 2 contingency tables with given marginals. Programs for determining the exact conditional tests and their power functions are provided for sample of size not exceeding 100. Large sample approximations based on maximum likelihood (ML) and on the arcsin transformation for proportions are studied.

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