Determination of antibiotic concentrations in bone

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Abstract
Cancellous and cortical bone specimens with added amounts of cefazolin, erythromycin and methicillin were homogenized in a vibration mill to a particle size between 0.3 and 2.4 μm. In cancellous bone the recoveries of cefazolin and erythromycin were about 100%, whereas for methicillin the recovery was about 50%. In cortical bone the recoveries ranged between 4 and 56% for all three antibiotics. The fall in antibiotic concentration was due mainly to the instability of the antibiotim during the 1 and 4 h homogenization procedures, whereas binding to the bone was found insignificant. In eight patients treated with erythromycin the cancellous bone concentration was found to be about ⅓of the serum concentrations.