Ynamines derived from nucleic acids bases: synthesis, reactivity and biological activity
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 6,p. 513-514
- https://doi.org/10.1039/c39920000513
Abstract
Ynamines 1a–d are prepared by alkylation of nucleic acids bases with tetrachloroethylene followed by elimination of halogens from the intermediates 4a–d; reaction of 1a with acetone and cyclohexanone gives carbinols 8a and b and in the case of 8b cyclic ketal 9a is also obtained; compound 1a is a substrate for adenosine deaminase.Keywords
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