Cimetidine and Mental Confusion

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Abstract
To the Editor: The recent introduction of the specific H-2 blocker, cimetidine, has met with widespread enthusiasm in the treatment of the patient with upper gastrointestinal bleeding who is too sick to be operated on. It is also favored as therapy in the hope of preventing stress ulceration in the critically ill patient with a peptic-ulcer diathesis. Recently, reports of Central-nervous-system toxicity have appeared in the literature.1 , 2 The course of the two patients described below was complicated by unexplained delirium and suggests that cimetidine may have been involved.Case 1. A previously alert 71-year-old stockbroker underwent cholecystectomy for an acute . . .

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