Pernicious Papillomavirus Infection

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Abstract
More than 100 years have passed since an association between sexual behavior and cancer of the cervix was reported. In the ensuing years, the elusive sexually transmitted agent has been intensively sought. It was not long ago that the herpes simplex virus (HSV) was thought to be this agent on the basis of serologic studies, and indeed, HSV remains in the collective consciousness of many physicians as a causative agent of cancer of the cervix, despite the lack of evidence supporting this conclusion. With the advent of recombinant DNA technology and the cloning of oncogenic human papillomaviruses (HPV), it became . . .