THE EFFECT OF AGE ON HUMAN CONE AND ROD GANZFELD ELECTRORETINOGRAMS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 20  (3) , 392-399
Abstract
The ganzfeld-evoked electroretinogram (ERG) is the most effective measure of the mass electrical response of cones and rods; all variables affecting the various components of the ERG are not identified. The scotopic b-wave amplitude is presumed age-dependent. Age dependency for other components is unclear. Linear regression analysis against age and multiple regression analysis against age and log intensity of the stimulus were performed on ERG responses from 24 prospectively normal subjects. Significant age dependency was found for scotopic rod-mediated b-wave amplitude, scotopic mixed rod-and cone-mediated bx-wave amplitude and for photopic cone-mediated b-wave amplitude. No significant age correlation was found for dark-adapted cone a-wave amplitude, scotopic cone-mediated x-wave amplitude, scotopic a-wave amplitude from mixed rod and cone responses to bright stimuli or for implicit times for scotopic or photopic responses. For clinical patient evaluation age-corrected normal ranges derived from linear or multiple regression coefficients are recommended for rod- and cone-mediated b-wave response; normal ranges derived from mean and standard deviation are more appropriate for scotopic a-wave amplitude, scotopic cone-mediated x-wave amplitude and for all implicit times.

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