Theta–gamma coupling increases during the learning of item–context associations
Top Cited Papers
- 8 December 2009
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 106 (49) , 20942-20947
- https://doi.org/10.1073/pnas.0911331106
Abstract
Phase-amplitude cross-frequency coupling (CFC) between theta (4–12 Hz) and gamma (30–100 Hz) oscillations occurs frequently in the hippocampus. However, it still remains unclear whether theta–gamma coupling has any functional significance. To address this issue, we studied CFC in local field potential oscillations recorded from the CA3 region of the dorsal hippocampus of rats as they learned to associate items with their spatial context. During the course of learning, the amplitude of the low gamma subband (30–60 Hz) became more strongly modulated by theta phase in CA3, and higher levels of theta–gamma modulation were maintained throughout overtraining sessions. Furthermore, the strength of theta–gamma coupling was directly correlated with the increase in performance accuracy during learning sessions. These findings suggest a role for hippocampal theta–gamma coupling in memory recall.Keywords
This publication has 34 references indexed in Scilit:
- Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneuronsProceedings of the National Academy of Sciences, 2009
- Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze taskProceedings of the National Academy of Sciences, 2008
- Low-frequency neuronal oscillations as instruments of sensory selectionPublished by Elsevier ,2008
- Entrainment of Neocortical Neurons and Gamma Oscillations by the Hippocampal Theta RhythmNeuron, 2008
- A Neural Coding Scheme Formed by the Combined Function of Gamma and Theta OscillationsSchizophrenia Bulletin, 2008
- On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampusProceedings of the National Academy of Sciences, 2007
- Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze taskProceedings of the National Academy of Sciences, 2007
- High Gamma Power Is Phase-Locked to Theta Oscillations in Human NeocortexScience, 2006
- The Hippocampus, Memory, and Place CellsNeuron, 1999
- Relating Hippocampal Circuitry to FunctionPublished by Elsevier ,1999