CORRELATION BETWEEN ANTIDIURETIC HORMONE EFFECT AND CHANGES IN RENAL EXCRETION OF CALCIUM IN RATS AND DOGS

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Abstract
Injections and infusions of various preparations of arginine- and lysine-vasopressin into hydrated dogs and rats caused an increased urinary excretion of calcium which was well correlated with the antidiuretic effect of these hormones. Synthetic oxytocin and lysyl-oxytocin had the same effects when they were given in doses which caused antidiuresis, but smaller doses had no effect on renal calcium excretion. These findings strengthen the hypothesis, previously advanced, that the mechanism of action of the antidiuretic hormone involves an effect on calcium in the distal part of the nephron. The hypothesis is advanced that shifts of cell membrane calcium were involved in the mechanism of action of several other hormones as well.