Improvement of Local Irritation induced with Intramuscular Injection of Tiamulin by Cyclodextrin Complexation
Open Access
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 102 (9) , 874-880
- https://doi.org/10.1248/yakushi1947.102.9_874
Abstract
Cyclodextrin [CyD] complexation reduced the local irritation induced by i.m. injection of tiamulin (TM). The inclusion complexations of TM with 3 cyclodextrins (.alpha.-, .beta.-, .gamma.-CyD) in aqueous solution and in solid phase was assessed by UV, circular dichroism, solubility method, thermal analyses and powder X-ray diffractometry. Effects of CyD on in vitro hemolysis induced by TM were investigated as a representation of local irritation. The protective effects of CyD against hemolysis caused by TM increased in the order of .gamma.- > .beta.- > .alpha.-CyD. The irritative effects of TM and its .gamma.-CyD complex on the vastus lateralis muscle of rabbits were studied on gross examination. TM showed a distinct discoloration of vastus lateralis muscle with surrounding hemorrhagic area. The irritation of .gamma.-CyD complex was milder than that of TM itself.Keywords
This publication has 1 reference indexed in Scilit:
- [27] Determination of binding stoichiometry by the continuous variation method: The job plotPublished by Elsevier ,2004