Calicheamicin θ: Durch Moleküldesign zu einer Verbindung, die DNA selektiv und effizient spaltet und Zelltod auslöst
- 16 January 1994
- journal article
- zuschrift
- Published by Wiley in Angewandte Chemie
- Vol. 106 (2) , 195-198
- https://doi.org/10.1002/ange.19941060210
Abstract
Durch den Angriff eines Thiolats an der Trisulfid‐Einheit wird das natürliche Calicheamicin γI1 1 zur Bildung eines Diradikals aktiviert, das dann DNA angreift. Das jetzt synthetisierte Thioacetat 2 ist noch einfacher – unter schwach basischen Bedingungen durch OH−Ionen – aktivierbar und zeigt ebenfalls biologisch äußerst interessante Eigenschaften. magnified imageKeywords
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