Rebound Gentamicin Levels After Hemodialysis

Publisher Website
Google Scholar
Abstract
After observing the phenomenon clinically, 7 post-hemodialysis patients were studied for a rebound effect of [the antibiotic] gentamicin levels. Serum gentamicin levels were obtained immediately after dialysis and 1 h postdialysis. An average 25.7% rebound occurred in the serum levels. A slow redistribution of gentamicin out of tissue into the serum was the probable mechanism. A short time period should be allowed before postdialysis levels are obtained to determine gentamicin replacement doses.