Inhibition by squalene of the tumor‐promoting activity of 12‐O‐Tetradecanoylphorbol‐13‐acetate in mouse‐skin carcinogenesis
- 2 December 1992
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 52 (6) , 950-952
- https://doi.org/10.1002/ijc.2910520620
Abstract
Squalene inhibited the effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), such as increased 32Pi incorporation into phospholipids of HeLa cell membrane, induction of Epstein-Barr-virus early antigen in Raji cell and induction of ornithine decarboxylase in mouse skin. Squalene also markedly suppressed the promoting activity of TPA on skin carcinogenesis in 7, 12-dimethylbenz[a]anthracene-initiated mice.Keywords
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