(S,S)-4,4′-Bis(3-hydroxy-estra-1,3,5(10),6,8-pentaene): An Efficient Ligand for the Catalytic Asymmetric Oxidation of Sulfides to Sulfoxides
- 1 March 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (3) , 360-362
- https://doi.org/10.1055/s-1999-2603
Abstract
Optically active sulfoxides are obtained by titanium-catalyzed oxidation of prochiral sulfides using tert-butyl hydroperoxide (TBHP) as oxidant and steroid-derived BINOL derivative (S,S)-1 as chiral ligand. Good yields and enantioselectivities of up to 92% ee have been achieved.Keywords
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