THE REGENERATION OF RECTAL EPITHELIUM IN THE RAT FOLLOWING WOUNDING WITH SUPPOSITORIES OF POLYOXYETHYLENE (23) LAURYL ETHER

  • 1 January 1983
    • journal article
    • research article
    • Vol. 64  (4) , 456-461
Abstract
The regeneration of the epithelial compartments of the rectal mucosa in rats was quantified at time intervals up to 1 wk following wounding with suppositories of the surfactant polyoxyethylene-(23)-lauryl ether. Regeneration of glandular tissue was complete within 1 wk of the wounding, with new glands arising from residual gland bases and from surface invagination of empty crypt skeletons and underlying granulation tissue. This method of wounding appears to be particularly useful for the study of epithelial regeneration since there was a minimal connective tissue response to the insult.