Induction of susceptibility to HgCl2 immune glomerulonephritis in the Lewis rat by immunocompetent cells from susceptible F1 hybrids

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Abstract
Susceptibility to HgCl2-induced glomerulonephritis was transferred to resistant Lewis (LEW) rats, irradiated and reconstituted with (LEW × BN)F1, hybrid immunocompetent cells. This glomerulonephritis was similar to that observed in Brown-Norway (BN) rats with a first stage characterized by anti-glomerular basement membrane antibodies and a second stage with immune complex-type deposits in the glomerular tufts and in the small renal arteries.