HISTOCOMPATIBILITY DIFFERENCE BETWEEN C3HfeB/HeN AND C3H/HeN MICE: TUMOUR INDUCED IN C3HfeB/HeN MICE EXPRESSES C3H/HeN‐ASSOCIATED ALLOANTIGEN

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Abstract
SUMMARY: A transplacentally induced lung tumour of C3HfeB/HeN mouse origin expresses, as a tumour‐associated antigen, a normal tissue component of strain A mice. The genetic locus coding for this alloantigen has been shown to be linked to the H‐2 major histocompatibility complex. In the present study we demonstrate that this antigen is also expressed on normal tissues of C3H/HeN mice. Skin grafts exchanged between C3HfeB/HeN and C3H/HeN mice are reciprocally rejected at approximately 3 weeks after grafting. C3HfeB/HeN mice were derived from C3H/HeN mice in 1945. These strains have apparently deviated since then in their genetic regulation of the expression of the MHC‐linked genetic locus. The finding of the C3H/HeN‐associated antigen on a C3HfeB/HeN mouse‐derived lung tumour indicates that this deviation is reversible.