Iontophoretically Induced Transdermal Delivery of Salbutamol

Publisher Website
Google Scholar
Abstract
Passive and iontophoretically assisted transport of salbutamol from a hydrogel matrix has been studied in vitro across a model membrane and in vivo and in vitro across human stratum corneum. in vitro experiments were conducted in specially designed glass diffusion cells and initial experiments using cellophane membranes showed that the passive release of salbutamol from the hydrogel across the membrane was matrix-controlled and that this transport could be significantly enhanced by the application of an iontophoretic current Passive diffusion of salbutamol from a gel matrix containing the sulphate through stratum corneum membranes, was found to be negligible over a 24 hour period, but significant transport could be induced using current densities in the range 0.04-0.4mA cm-2. The quantity of drug transported increased linearly with time, and was proportional to the current density used. Preliminary in vivo trials in two subjects showed significant electrically assisted systemic delivery of the drug using iontophoretic currents of 0.1 - 0.2mA over a 4 hour period.