Adenocarcinoma of the pancreas of childhood: a report of two cases

Abstract
The clinical, gross anatomical, light microscopic and ultrastructural features of 2 cases of adenocarcinoma of the pancreas of childhood are presented and compared with adult carcinoma of the pancreas. Both tumors showed acinar differentiation and zymogen granules were demonstrated by EM. A limited immunohistochemical study suggests that staining for .alpha.I-antitrypsin may provide a marker for acinar differentiation. The histogenesis of this tumor is discussed in relation to the possible origins of islet cells.