STUDY OF MULTIPLIED CORTICAL RESPONSE TO REPETITIVE STIMULATION IN THALAMUS

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Abstract
In young adult rabbits under MgSO4 anesthesia supplemented with ether, records were obtained of thalamic and cortical responses to repetitive electrical stimulation in the thalamic nuclei, usually the lateral ge-niculate nucleus. During brief periods of stimulation the cortical response to each stimulus was found to multiply and increase in voltage so that 2 and sometimes 3 high-voltage cortical deflections were obtained for each of a series of stimuli. When stimulation was interrupted, the multiplied response continued into the post-stimulatory record as the well-known after-discharges. The form of the multiplied response sequences was similar to that of strychnine spikes, and their appearance during repetitive stimulation was blocked readily by ether anesthesia. Coincident records from thalamus and cortex during the after-discharge period frequently showed excellent synchrony early in the discharge, but the thalamic and cortical patterns might then lose their synchronous character and after-discharge disappear in one before it did in the other. The high-voltage multiplied response and after-discharge patterns were believed to relate to activity in Bartley and Bishop''s specific response component of the thalamo-cortical mechanism.

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