ISOLATION AND STRUCTURAL ELUCIDATION OF URINARY METABOLITES OF CIPROFLOXACIN
- 1 January 1986
- journal article
- research article
- Vol. 36-2 (10) , 1545-1549
Abstract
After oral administration of 1-cyclopropyl-6-fluoro-1,4-dihydro-1-oxo-7-piperazine-1-ylquinoline-3-carboxylic acid (ciprofloxacin, Bay o 9867; designated trademark: Ciprobay) four metabolites M1-M4 were isolated from human urine by Craig counter current distribution and semipreparative high-performance liquid chromatography. Their molecular structures were elucidated by nuclear magnetic resonance and mass spectrometry and confirmed by comparing their spectra with those of authentic synthetic reference compounds.This publication has 7 references indexed in Scilit:
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