INDIVIDUAL VARIATION IN THE DISTRIBUTION OF LENS POTENCY IN WOLFFIAN LENS REGENERATION

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Abstract
After lentectomy in newts [Triturus pyrrhogaster], lens regeneration originates from the iris. The regenerant was externally observed with a stereomicroscope as a depigmented area (DA) of the iris, and the extent of DA up to 15 days after lentectomy was measured. The extent of DA differed among individuals; it was the same in both eyes of each animal. In a number of animals 1 eye was used for lentectomy. After measuring the DA, 2 groups of animals were selected; a W-group with an extremely wide DA that deviated from the standard value, and an N-group with an extremely narrow DA. Six iris sectors obtained from the animals of the W-group or N-group were implanted into lentectomized eyes of other animals to investigate the difference in the distribution of lens potency in these 2 groups. Animals of the W-group possessed a wider distribution of lens potency than animals of the N-group. Pulse-labeling with 3H-thymidine on lentectomized eyes of both groups was done 0, 3, 5, 7 and 12 days after lentectomy. DNA synthesis began earlier and continued longer in the dorsal part of the iris of the W-group than in that of the N-group. The distribution of lens potency in the iris was discussed.

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