THE CHEMICAL MEDIATION OF SYMPATHETIC VASODILATOR NERVE IMPULSES

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Abstract
In anesthetized cats, dogs and rabbits, injected with ergotoxine, the changes of blood pressure evoked by adrenine, acetylcholine and stimulation of the lower abdominal sympathetic chains were recorded before and after cocaine, eserine and atropine. In cats and dogs cocaine increases the fall caused by adrenine and the delayed rise elicited by sympathetic stimulation; eserine increases the initial fall elicited by sympathetic stimulation; and atropine diminishes or abolishes this initial fall and may change the delayed rise into a slight delayed fall. In rabbits stimulation of the lower abdominal sympathetic chains does not evoke a fall of blood pressure after ergotoxine. It is concluded that the effects of adrenine are specific and not mediated by acetylcholine; that the sympathetic contains some cholinergic and some adrenergic vasodilators in cats and dogs, and no vasodilators at all in the rabbit.

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