Alteration in Glutathione Metabolism during Cataract Progression

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Abstract
Human cataractous lenses obtained from eye relief camp showed decreased levels of sulphydryl and glutathione. Significant depletion in activities of glutathione reductase, glutathione peroxidase and glutose-6-phosphate dehydrogenase was also encountered. These findings indicated an impairment in glutathione metabolism of the mature cataractous lenses as compared to immature lenses, and oxidative stress could be considered as a primary event in this process.