Impaired fear memories are correlated with subregion-specific deficits in hippocampal and amygdalar LTP.
- 1 January 2005
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 119 (1) , 38-54
- https://doi.org/10.1037/0735-7044.119.1.38
Abstract
Inbred mouse strains have different genetic backgrounds that likely influence memory and long-term potentiation (LTP). LTP, a form of synaptic plasticity, is a candidate cellular mechanism for some forms of learning and memory. Strains with impaired fear memory may have selective LTP deficits in different hippocampal subregions or in the amygdala. The authors assessed fear memory in 4 inbred strains: C57BL/6NCrlBR (B6), 129S1/SvImJ (129), C3H/HeJ (C3H), and DBA/2J (D2). The authors also measured LTP in the hippocampal Schaeffer collateral (SC) and medial perforant pathways (MPP) and in the basolateral amygdala. Contextual and cued fear memory, and SC and amygdalar LTP, were intact in B6 and 129, but all were impaired in C3H and D2. MPP LTP was similar in all 4 strains. Thus, SC, but not MPP, LTP correlates with hippocampus-dependent contextual memory expression, and amygdalar LTP correlates with amygdala-dependent cued memory expression, in these inbred strains.Keywords
This publication has 102 references indexed in Scilit:
- Synaptic Plasticity in the AmygdalaAnnals of the New York Academy of Sciences, 2006
- Multidisciplinary approaches for investigating the mechanisms of hippocampus-dependent memory: a focus on inbred mouse strainsNeuroscience & Biobehavioral Reviews, 2004
- Modulation of Hippocampal Long-Term Potentiation by the Amygdala: A Synaptic Mechanism Linking Emotion and MemoryThe Japanese Journal of Pharmacology, 2001
- Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1Hippocampus, 2001
- Water maze and radial maze learning and the density of binding sites of glutamate, GABA, and serotonin receptors in the hippocampus of inbred mouse strainsHippocampus, 2000
- Deficiency in induction but not expression of LTP in hippocampal slices from young rats.Learning & Memory, 1996
- Lack of strain differences in spatial learning among seizure-prone and seizure-resistant miceBehavior Genetics, 1993
- Spatial selectivity of unit activity in the hippocampal granular layerHippocampus, 1993
- Differences between inbred strains of mice in Morris water maze performanceBehavior Genetics, 1988
- LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONSJournal of Neurology, Neurosurgery & Psychiatry, 1957