HISTOLOGIC-STUDY OF THE EARLY EVENTS IN OXALATE INDUCED INTRA-NEPHRONIC CALCULOSIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 17  (3) , 199-202
Abstract
The early phases of calcium oxalate crystal formation in rat kidneys after i.p. challenge with sodium oxalate were examined. The crystals are formed intraluminally in the proximal tubules of the renal cortex. The size, number and distribution of calcium oxalate particles depend on the amount of sodium oxalate injected and the time interval after its injection. Tubular necrosis and dilation were evident after administration of higher doses of sodium oxalate. The papillary tip and corticomedullary junction were the preferential sites for crystal localization after longer periods of injections of higher doses of sodium oxalate.

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