A third human CALC (pseudo)gene on chromosome 11
- 6 June 1988
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 233 (1) , 57-63
- https://doi.org/10.1016/0014-5793(88)81355-3
Abstract
A genomic locus in man (CALC‐III) containing nucleotide sequences highly homologous to both exon 2 and exon 3 of the CALC‐I and ‐II genes, is described in this paper. The CALC‐I gene produces calcitonin (CT) (encoded by exon 4) or calcitonin gene‐related peptide (CGRP) (encoded by exon 5) in a tissue‐specific fashion. The CALC‐II gene produces a second human CGRP, but probably not a second CT. The CALC‐III gene does not seem to encode a CT‐ or CGRP‐related polypeptide hormone and is probably a pseudogene. Like the other two CALC genes, the CALC‐III gene is located on human chromosome 11.Keywords
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