Selective and Potent In Vitro Antimalarial Activities Found in Four Microbial Metabolites
- 1 March 2007
- journal article
- Published by Springer Nature in The Journal of Antibiotics
- Vol. 60 (3) , 220-222
- https://doi.org/10.1038/ja.2007.27
Abstract
Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in the Kitasato Institute chemical library. Hedamycin showed selective and potent activity against both drug-resistant and drug-sensitive strains of Plasmodium falciparum. Simaomicin exhibited remarkably strong antimalarial activity, although its activity against a drug-resistant strain was weaker than that against a drug-sensitive strain. The antimalarial effects of triacsins C and D are also reported.Keywords
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