Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies
Open Access
- 1 June 2001
- journal article
- review article
- Published by Springer Nature in Cell Research
- Vol. 11 (2) , 85-88
- https://doi.org/10.1038/sj.cr.7290071
Abstract
Directional migration of leukocytes is indispensable to innate immunity for host defense. However, recruitment of leukocytes to a site of tissue injury also constitutes a leading cause for inflammatory responses. Mechanistically, it involves a cascade of cellular events precisely regulated by temporal and spatial presentation of a repertoire of molecules in the migrating leukocytes and their surroundings (microenvironments). Here I will summarize the emerging evidence that has shed lights on the underlying molecular mechanism for directional migration of leukocytes, which has guided the therapeutical development for innovative anti-inflammatory medicines.Keywords
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