ABSENCE OF SEROLOGICALLY DETECTABLE H-2 ON PRIMITIVE TERATOCARCINOMA CELLS IN CULTURE

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Abstract
A primitive teratocarcinoma (PTC) cell line (F9) possesses a strong antigen that elicits the formation of specific antibodies in syngeneic mice. This antigen is also present on morula cells and it is specified by a wild type gene of a recessive lethal T locus mutant affecting morula cells. Because of this antigenic similarity between morula and PTC cells, the presence of H-2 antigen on PTC cells was investigated. The results bring additional support to the similarity between morula and F9 cells. They also support the suggestion that there may be a reciprocal relationship between H-2 and early embryonic antigens, specifically those determined by the T locus which is on the same chromosome as H-2. One wild type t antigen appears to be switched on in morulae and off in adult cells (with the exception of sperm), while H-2 appears to be switched off in morulae and progressively turned on in later embryogenesis.

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