Linkage of Gene for C2 Deficiency and the Major Histocompatibility Complex MHC in Man Family Study of a Further Case1

Publisher Website
Google Scholar
Abstract
Close linkage between HL-A and C2 [secondary component of complement] deficiency was 1st reported. A pedigree of a 31 yr old C2-deficient individual with clinical manifestations of Hodgkin''s disease is presented. The following markers were tested: C2 levels, factor B polymorphism, blood groups and enzyme typing. Besides close linkage between HL-A and C2 deficiency, both parents were heterozygous for Bf (HL-A linked, electrophoretic variation of B). The 2 HL-A haplotypes closely linked to C2 deficiency are different: 2,W18 and W24,W18. They shared the SD2 [serum determined antigen) antigen W18 and the LD [lymphocyte determined antigen] type 7a.