Asymmetric γ-Methylation of Allylic Grignard Reagents Using a Chiral Leaving Group

Publisher Website
Google Scholar
Abstract
The asymmetric γ-methylation of allylic Grignard reagents was achieved using a chiral leaving group. Optically active methyl 1,1’-binaphthyl-2,2’-diylphosphate reacted with various cinnamyl Grignard reagents to afford the corresponding γ-methylated products with up to 48% ee. Construction of a chiral quaternary carbon center was also accomplished by this method.

This publication has 0 references indexed in Scilit: