LARGE MONONUCLEAR IA-POSITIVE VEILED CELLS IN PEYERS PATCHES .1. ISOLATION AND CHARACTERIZATION IN RAT, GUINEA-PIG AND PIG

  • 1 January 1983
    • journal article
    • research article
    • Vol. 48  (3) , 453-460
Abstract
The antigen presenting cell system in the skin is extensively studied, and is supposed to consist of Langerhans cells in epidermis and dermis, veiled cells in skin lymph and interdigitating cells in skin lymph nodes. To detect whether a similar cell system is present in the gut, Peyer''s patch cell suspensions were studied. Mononuclear cells with long actively moving cytoplasmic veils were found in cell suspensions from Peyer''s patches of rat, guinea pig and pig, and in cell suspensions from small intestinal villi of guinea pig and pig, but not of rat. These veiled cells are strongly Ia-positive. Because of their Ia positivity, their enzyme cytochemical staining pattern and their ultrastructure, these cells resemble the antigen presenting cells of the skin, skin lymph and lymph node.