INHIBITION OF A STAPHYLOCOCCAL HEMOLYSIN BY A SOLUBLE SUBSTANCE PRODUCED BY A NONHEMOLYTIC MICROCOCCUS SPECIES

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Abstract
The delta-hemolysin of staphylococci was found to be inhibited by a soluble substance produced by a nonhemolytic yellow pigment forming Micrococcus sp. The production of this hemolysis inhibiting substance seemed to be quite common because all of the 5 strains of yellow pigment forming Micrococcus sp. isolated from clinical materials were found to produce this substance. The hemolysin inhibiting substance has no effect on the human red cells, and its activity is exhibited by combining directly with the delta-hemolysin. This substance seems to be a protein in nature, and a possible mode of its production and activity is discussed.

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