Impact of Metabolic Syndrome on the Development of Cardiovascular Disease in a General Japanese Population
- 1 July 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 38 (7) , 2063-2069
- https://doi.org/10.1161/strokeaha.106.479642
Abstract
Background and Purpose— The metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease (CVD) events in general populations. However, well-designed prospective studies in Asian populations are very limited. Methods— We prospectively evaluated a total of 2452 community-dwelling Japanese individuals aged 40 years or older from 1988 to 2002 and examined the effects of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria on incident CVD. Results— The prevalence of the MetS was 21% in men and 30% in women at baseline. During the follow up, 307 CVD events occurred. Compared with those without MetS, the age-adjusted incidence of CVD (per 1000 person-years) was significantly higher in subjects with the MetS in both men (21.8 versus 11.6, P<0.01) and women (12.9 versus 6.5, P<0.01). The risk of CVD events was significantly higher even after adjusting for the following confounding factors: age, proteinuria, electrocardiographic abnormali...Keywords
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