Thrombo-angiitis obliterans usually affects men between the ages of 20 and 45 years. Although approximately seven hundred cases of thrombo-angiitis obliterans have been observed at the Mayo Clinic, the present report of ten cases is the first series among women to be put on record. The diagnosis in three of these cases was proved by a study of the pathologic changes in the occluded arteries and veins. Only three acceptable cases have been reported in the literature (cases 1, 2 and 3). In 1924, Buerger1 made a clinical diagnosis of the condition of two women without proof of pathologic changes. In 1925, Meleney and Miller2 reported that they had observed a Chinese woman with thrombo-angiitis obliterans; their study of the occluded vessels leaves no doubt as to the diagnosis. Koyano3 reported the case of a woman, aged 55, in whom a peculiar vascular disturbance had appeared in