DIPYRIDAMOLE: A POTENT STIMULATOR OF PROSTACYCLIN (PGI2) BIOSYNTHESIS
Open Access
- 1 January 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 68 (1) , 71-73
- https://doi.org/10.1111/j.1476-5381.1980.tb10700.x
Abstract
1 Dipyridamole (0.01 to 0.75 mm) increased prostacyclin (PGI2) biosynthesis from tritiated arachidonic acid in rat stomach fundus homogenates by 21 to 350%. The transformation of prostaglandin H2 (PGH2) to PGI2 by a microsomal fraction of pig aorta was stimulated by dipyridamole at 0.1 m by 63% 2 In the isolated perfused heart of the rabbit dipyridamole at 1 and 5 μg/ml increased PGI2 release by 70% and 146% respectively. 3 Our results show a stimulation of the second step in PGI2 biosynthesis (from endoperoxides) by dipyridamole. This effect should be considered in relation to the therapeutic usage of the drug in myocardial infarction.Keywords
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