Inactivation of Platelet-derived Growth Factor Receptor by the Tumor Suppressor PTEN Provides a Novel Mechanism of Action of the Phosphatase
Open Access
- 1 April 2004
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 279 (15) , 15258-15268
- https://doi.org/10.1074/jbc.m314328200
Abstract
No abstract availableKeywords
This publication has 51 references indexed in Scilit:
- Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene TranscriptionJournal of Biological Chemistry, 2002
- Ceramide Blocks PDGF-Induced DNA Synthesis in Mesangial Cells via Inhibition of Akt Kinase in the Absence of ApoptosisBiochemical and Biophysical Research Communications, 2001
- Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent PathwaysDevelopmental Biology, 2000
- Crystal Structure of the PTEN Tumor SuppressorCell, 1999
- Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systemsProceedings of the National Academy of Sciences, 1999
- High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceCurrent Biology, 1998
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTENScience, 1998
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997
- Phorbol 12‐myristate 13‐acetic acid inhibits PTP1B activity in human mesangial cells A possible mechanism of enhanced tyrosine phosphorylationFEBS Letters, 1994