Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination
Open Access
- 1 August 2006
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (8) , 4954-4959
- https://doi.org/10.1128/iai.01781-05
Abstract
Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection againstMycobacterium tuberculosis.Keywords
This publication has 31 references indexed in Scilit:
- Rapid Recruitment of Virus-Specific CD8 T Cells Restructures Immunodominance during Protective Secondary ResponsesJournal of Virology, 2005
- Complex Memory T-Cell Phenotypes Revealed by Coexpression of CD62L and CCR7Journal of Virology, 2005
- Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infection model after aerosol infection of mice with Mycobacterium tuberculosisGene Therapy, 2003
- Preferential Localization of Effector Memory Cells in Nonlymphoid TissueScience, 2001
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999
- In vitro and in vivo release properties of brilliant blue and tumour necrosis factor-alpha (TNF-alpha) from poly(D,L-lacticco-glycolic acid) multiphase microspheresJournal of Microencapsulation, 1999
- Factors Affecting the in Vitro Release of Recombinant Human Interferon-γ (rhIFN-γ) from PLGA MicrospheresJournal of Pharmaceutical Sciences, 1997
- Key epitopes on the secreted ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosisImmunology Letters, 1997
- Regulation of antibody isotype secretion by subsets of antigen-specific helper T cellsNature, 1988
- Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype ProductionScience, 1987