Selective and continuous-flow mono-methylation of arylacetonitriles with dimethyl carbonate under gas-liquid phase-transfer catalysis conditions
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 5,p. 1070-1071
- https://doi.org/10.1039/p19890001070
Abstract
Very high selectivity in monomethylation of arylacetonitriles is observed when dimethyl carbonate is used as an alkylating agent under g.l.-p.t.c. conditions: thus phenylacetonitrile, reacting on a catalytic bed of corundum spheres coated with K2CO3 and polyethyleneglycol, yields 2-phenylpropionitrile with only 1% of bismethylated by-product. The method is a new, one-step, general route to the synthesis of 2-arylpropionitriles.This publication has 0 references indexed in Scilit: