Modification of the embryo-maternal relationship in ewes by progesterone treatment early in the oestrous cycle

Abstract
When 25 mg progesterone/day were injected into ewes on days 0-3 of the estrous cycle, the subsequent cycle was shortened by 4 days and on day 6 such ewes provided an acceptable uterine environment for the survival of 10-day-old embryos. Exposure of the non-pregnant uterus to .apprx. 8 days of normal luteal concentrations of progesterone may be necessary to initiate luteolysis.