Inhibition of lipid peroxidation by methylated analogues of uric acid

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Abstract
The effects of purines and methylated purine analogues on hydrogen peroxide- and ozone-induced lipid peroxidation in human erythrocyte membranes were studied in-vitro. Many purines and purine analogues showed a suppressive effect on the formation of thiobarbituric acid reactive materials. 1,3-Dimethyluric acid and 1,3,7-trimethyluric acid showed high potency in prevention of lipid peroxidation. These effects were shown to be concentration dependent and were more potent at low concentrations of hydrogen peroxide and ozone. 1,3-Dimethyluric acid and 1,3,7-trimethyluric acid may be useful as antioxidants.