Hepatic 3-Hydroxy-3-Methylglutaryl CoA Reductase Activity in Germfree Rats

1 March 1977

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 154 (3) , 319-321
https://doi.org/10.3181/00379727-154-39662

Abstract

The cholesterol synthesis was studied in germfree and conventional rats by assaying the HMG CoA (3-hydroxy-3-methylglutaryl CoA) reductase activity in the liver microsomal fraction. Germfree rats had a decreased activity (21.7 .+-. 3.8 pmol/mg of protein/min) compared with conventional rats (50.5 .+-. 2.9). The results are discussed in relation to present knowledge of cholesterol metabolism in the 2 tyPes of animals.

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