Sequence accuracy of large DNA sequencing projects
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in DNA Sequence
- Vol. 2 (6) , 335-342
- https://doi.org/10.3109/10425179209020814
Abstract
Very little information has been accumulated regarding the likely accuracy of final or consensus DNA sequence data. With the large-scale efforts anticipated for the Human Genome Project, the subjective determination of final sequence must eventually be replaced with more objective, automatic methods. This will require a much better understanding of the nature of error in raw sequencing data and its impact on the determination of the final sequence. This paper describes a start at defining the error model of large-scale sequencing efforts based on random subcloning strategies.Keywords
This publication has 5 references indexed in Scilit:
- Large-Scale and Automated DNA Sequence DeterminationScience, 1991
- Large-scale DNA sequencingCurrent Opinion in Biotechnology, 1991
- Large-Scale Sequencing Trials BeginScience, 1990
- Sequencing of megabase plus DNA by hybridization: Theory of the methodGenomics, 1989
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977