Pharmacokinetic Properties of Testosterone Propionate in Norman Men
- 1 December 1986
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 63 (6) , 1361-1364
- https://doi.org/10.1210/jcem-63-6-1361
Abstract
The pharmacokinetic characteristics of testosterone propionate were studied in normal men after a single im dose of 25 mg testosterone propionate-19,i9,19-d3; Plasma levels of testosterone propionate-19,19,19-d3, its active metabolite testosterone-i9,19,19-d3, and endogenous testosterone were measured by gas chromatography-mass spectrometry. Testosterone propionate-19,19,l9-d3 was gradually transferred from the im injection site to the systemic circulation. The plasma levels of testosterone propionate-19,l9,19-d3 were maintained at 2–4 ng/ ml between 3 and 36 h after administration. Plasma testosterone-i9,19,19-d3 levels were maintained above the physiological testosterone level for 48 h, while plasma levels of endogenous testosterone changed little.Keywords
This publication has 10 references indexed in Scilit:
- Stable-Isotope Methodology in the Bioavailability Study of 17α-Methyltestosterone using Gas Chromatography-Mass SpectrometryJournal of Pharmaceutical Sciences, 1986
- Determination of testosterone propionate in human plasma by gas chromatography— mass spectrometryJournal of Chromatography B: Biomedical Sciences and Applications, 1985
- Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal menInternational Journal of Andrology, 1984
- In vivo patterns of circulating testosterone following castration and intramuscular testosterone propionate injections of adult male ratsSteroids, 1983
- Comparison of the kinetics of injectable testosterone in eugonadal and hypogonadal menFertility and Sterility, 1982
- Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in menActa Endocrinologica, 1981
- High-performance liquid chromatographic analysis of testosterone esters in oily solutionJournal of Pharmaceutical Sciences, 1980
- Differentiation between Endogenous and Exogenous Testosterone in Human Plasmaand Urine after Oral Administration of Deuterium-Labeled Testosterone by Mass FragmentographyJournal of Clinical Endocrinology & Metabolism, 1980
- Determination of plasma testosterone by mass fragmentography using testosterone-19-d3 as an internal standardJournal of Chromatography B: Biomedical Sciences and Applications, 1979
- Bioavailability and LH-Suppressing Effect of Different Testosterone Preparations in Normal and Hypogonadal MenHormone Research, 1976