MIDAZOLAM KINETICS BEFORE, DURING AND AFTER CARDIOPULMONARY BYPASS-SURGERY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 5  (2) , 123-126
Abstract
Gas-chromatographically determined serum concentrations of midazolam were recorded before, during and after cardiopulmonary bypass in patients scheduled for a coronary artery bypass grafting operation. Following single 0.075 mg/kg (n = 6) and 0.15 mg/kg (n = 6) i.v. injections of midazolam, a mean distribution phase half-life of 3.4 and 4.4 min, respectively, was calculated. At the establishment of the bypass, a rapid drop in the concentration of midazolam was observed followed by a significant increase in concentration during the postperfusion period. The apparent mean elimination phase half-life (281 min) of midazolam was longer than that (.apprx. 120 min) measured in earlier works in young, healthy subjects. The metabolism of midazolam during the postperfusion period appears to be slower.

This publication has 1 reference indexed in Scilit: