Genetic control of major histocompatibility complex-linked immune responses to synthetic polypeptides in man.

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Abstract
Vigorous lymphocyte proliferative response to synthetic polypeptides was observed in cells from 50 normal volunteers. A total of 64% responded to poly(LHis, LGlu)-poly(DLAla).sbd.poly(LLys) [(H, G)-A.sbd.L] and 54% to poly(LTyr, LGlu)-poly(DLAla).sbd.poly(LLys) [(T, G)-A.sbd.L]. Subjects could be classified into high-, intermediate- and non-responder phenotypes according to their stimulation indices. High responses to these antigens are inherited as HLA-linked dominant traits. Two matings suggested gene complementation in response to (T, G)-A.sbd.L and (H, G)-A.sbd.L. One, with an intra-HLA recombinant off-spring, provided evidence localizing the immune response gene(s) controlling lymphocyte proliferation to (T, G)-A.sbd.L and (H, G)-A.sbd.L, presumably the homolog to Ir-1 of mouse, closer to the HLA-B than to the HLA-D region.