Expression of transforming growth factor beta superfamily and their receptors in the corneal stromal wound healing process after excimer laser keratectomy
Open Access
- 1 April 1998
- journal article
- letter
- Published by BMJ in British Journal of Ophthalmology
- Vol. 82 (4) , 456g
- https://doi.org/10.1136/bjo.82.4.456g
Abstract
Editor,—Corneal stromal clouding (corneal haze) develops after excimer laser keratectomy. During the corneal wound healing process after excimer laser keratectomy, abnormal subepithelial fibrous tissue is formed just under the abraded area, where keratocytes proliferate and extracellular matrix (ECM) components, including collagens (type III, IV, and VII), fibronectin, laminin, and tenascin, are deposited.1-3 This abnormal ECM deposition is thought to correspond to the corneal haze. The transforming growth factor β (TGF-β) superfamily contains many multifunctional proteins, including TGF-βs, activins, and bone morphogenetic proteins (BMPs).4 They regulate cellular proliferation, differentiation, migration, and ECM production.4 Through these functions, TGF-β is known to regulate the wound healing process in many tissue. For example, TGF-β accelerates the abnormal …Keywords
This publication has 0 references indexed in Scilit: