Depression of spasticity by alpha-adrenergic blockade

Publisher Website
Google Scholar
Abstract
In spastic patients the .alpha.-adrenergic blocking drug thymoxamine (Opilon Forte) was capable of depressing most proprioceptive reflex parameters within 1 min after i.v. administration. The action seems to be of CNS origin, probably exerted as a depression of spindle stretch sensitivity through descending .alpha.-adrenergic bulbo-spinal pathways, but an additional action on the mechanism of presynaptic inhibition is likely. With oral administration, the drug is also capable of depressing distressing clonus and deserves further testing as a spasmolytic.

This publication has 14 references indexed in Scilit: