Reflex Changes in Pulmonary Hemodynamics Resulting from Microembolism

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Abstract
A technic is described for controlled in vivo perfusion of the left upper lobe of the dog lung, preserving innervation, negative intrathoracic pressure, and spontaneous respiration. Changes in pulmonary vascular resistance in this system were studied after selective microembolization of the right lung and the left vascular resistance lower lobe with glass spheres 50 µm in diameter. A transient vasospasm was ellicited by microembolization of the ipsilateral lung. This reflex was not abolished by severing the thoracic sympathetic and vagus nerves. Reimplantation of the left lower lobe prior to emboli-zation prevented a reflex increase in resistance of the isolated perfused lobe.

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